AILERON Therapeutics is a biopharmaceutical company developing a breakthrough class of drugs called Stapled Peptides. This new class of drugs represents the first general solution for modulating intracellular protein-protein interactions, which have been identified as critical control points for most human diseases. Aileron's new therapeutic modality creates a unique opportunity to exploit potentially thousands of currently "undruggable" targets with applications in all human diseases.

Stapled Peptide Targets

Stapled Peptides target intracellular control points that cannot be modulated by current therapeutics.

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Stapled Peptides are produced by connecting two structurally optimized amino acids.

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News

November 11, 2009
Aileron Therapeutics Collaborators Publish In Vivo Research in Nature Showing Stapled Peptides Achieve the First Direct Inhibition of the Notch1 Transcription Factor Oncogene
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October 19, 2009
Aileron Appoints Steven Kafka, PhD, as Company's First Chief Financial Officer and Vice President, Finance and Operations.
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September 30, 2009
Aileron Appoints Industry Veteran Diane Jorkasky, M.D., as Company's Head of Development and Chief Medical Officer.
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June 8, 2009
Aileron Therapeutics Closes $40 Million Series D Financing
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Recent Publications

Aileron Therapeutics Collaborators Publish In Vivo Research in Nature Showing Stapled Peptides Achieve the First Direct Inhibition of the Notch1 Transcription Factor Oncogene.
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In an article published in Nature, Aileron’s proprietary Stapled Peptide drug candidate was shown to target a new and fundamental therapeutic mechanism.
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