Posts in ALRN-6924
Dual inhibition of MDMX and MDM2 as a Therapeutic Strategy in Leukemia.

L. A. Carvajal, D. Ben Neriah, A. Senecal, L. Benard, V. Thiruthuvanathan, T. Yatsenko, S.-R. Narayanagari, J. C. Wheat, T. I. Todorova, K. M. Mitchell, C. Kenworthy, V. Guerlavais, D. A. Annis, B. Bartholdy, Britta Will, J. D. Anampa, I. Mantzaris, M. Aivado, R. H. Singer, R. A. Coleman, A.Verma, U. Steidl. Sci Transl Med. 2018, 10(436). pii: eaao3003

https://stm.sciencemag.org/content/10/436/eaao3003/tab-pdf

Article highlighted in The Hematologist

https://www.hematology.org/Thehematologist/Diffusion/8673.aspx

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ALRN-6924Liz Tompkins
Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models.

S. Y. Ng, N. Yoshida, A. L. Christie, M. Ghandi, N. V. Dharia, J. Dempster, M. Murakami, K. Shigemori, S. N. Morrow, A. Van Scoyk, N. A. Cordero, K. E. Stevenson, M. Puligandla, B. Haas, C. Lo, R. Meyers, G. Gao, A. Cherniack, A. Louissaint JR, V. Nardi, A. R. Thorner, H. Long, X. Qiu, E. A. Morgan, D. M. Dorfman, D. Fiore, J. Jang, A. L. Epstein, A. Dogan, Y. Zhang, S. M. Horwitz, E. D. Jacobsen, S. Santiago, J.-G. Ren, V. Guerlavais, D. A. Annis, M. Aivado, M. N. Saleh, A. Mehta, A. Tsherniak, D. Root, F. Vazquez, W. C. Hahn, G. Inghirami, J. C. Aster, D. M. Weinstock, R. Koch, Nat Commun. 2018, 22, 9(1) : 2024

https://www.nature.com/articles/s41467-018-04356-9

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ALRN-6924Liz Tompkins
Phase I trial of a novel stapled peptide ALRN-6924 disrupting MDMX- and MDM2-mediated inhibition of WT p53 in patients with solid tumors and lymphomas.

Funda Meric-Bernstam, Mansoor N. Saleh, Jeffrey R. Infante, Sanjay Goel, Gerald Steven Falchook, Geoffrey Shapiro, Ki Y Chung, Robert Martin Conry, David S. Hong, Judy Sing-Zan Wang, Ulrich Steidl, Loren D. Walensky, Vincent Guerlavais, Marie Payton, D. Allen Annis, Manuel Aivado, and Manish R. Patel. Phase I trial of a novel stapled peptide ALRN-6924 disrupting MDMX- and MDM2-mediated inhibition of WT p53 in patients with solid tumors and lymphomas. J of Clin Oncol. 35:15_suppl, 2505-2505 (2017)

https://ascopubs.org/doi/abs/10.1200/JCO.2017.35.15_suppl.2505

https://investors.aileronrx.com/static-files/1bd4ccdb-c057-4aea-a83f-9076761ba416

Abstract highlighted in Journal Clinical Oncology (ASCO Special article)

https://ascopubs.org/doi/pdf/10.1200/JCO.2017.77.0446

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ALRN-6924Liz Tompkins